The ongoing COVID-19 pandemic has laid bare our collective weaknesses in being able to effectively respond to
the emergence of a highly contagious and lethal microbial threat. Despite extraordinary advances over the past
century in science and unprecedented improvement in global health standards, as evidenced by the COVID-19
pandemic, we still live in a world where the threat an infectious agent can emerge without warning and spread
rapidly to every household and every community and every household without regard to national borders or to
social and economic standing.
Over the course of the remainder of this century, the likely frequency of epidemics and pandemics will continue to
increase, driven to a large extent by demographic trends, including urbanization, and environmental degradation
and climate change, persistent social and economic inequalities, and globalized trade and travel. The burden of
these diseases is not equally distributed across the world; the economically disenfranchised, displaced
populations and people living with pre-existing conditions are disproportionately impacted.
Importantly, the drivers underlying the emergence of novel disease threats are complex human behaviors and
their impact on animal populations and the environment are understood to be central to their emergence.
Changing environmental and climatic conditions have been closely linked to the emergence of novel infectious
diseases and the redistribution of those already existing. Their aggregate impact will continue to increase over the
course of this century.
While the upgrading of the health security apparatus over the last decade has been welcomed COVID-19
underscores that these processes and institutional arrangements are not sufficient to responding to events like
SARS-COV 2. Compliance with the International Health Regulations (2005), that provide a normative framework
for surveillance, preparedness, notification and international support and coordination has also been shown to be
inadequate. The experience of the COVID-19 pandemic underscores that new efforts need to be made to craft
global strategies, policies and regulatory frameworks that more directly address the multi-sectoral aspects of
disease emergence in order to improve our collective capacities to prevent, detect and respond to threats. Key is
strengthening key multi-sectoral systems, increasing policy coherence, including in health technologies access
and innovation, and reducing risks of new disease threats.
The failure of the world’s response to the COVID-19 pandemic, however, is not simply about the virus’s biology
and its ecology, nor the inadequacies of our multi-sectoral partnerships. The erosion of support over the past
decade for multilateral institutions and partnerships, a growing mistrust between citizens and their leaders, and
the rise of “anti-science” have further complicated the ability of nations to mount an effective coordinated global
response to global events like COVID-19. We need to thoughtfully examine the causes underlying these trends,
including the expanding impact of social media, if we are to understand their contributions to the failure of an
effective response to the COVID-19 pandemic; and based on this insight develop new strategies to re-invigorate
our commitment to multilateral partnerships, build more trustful relationships between governments and their
citizens, and re-affirm the centrality of evidence-based solutions to future threats.